Panadol is a drug that belongs to the group of analgesics and antipyretics, i.e. it has 2 main effects: analgesic and antipyretic. The active ingredient of Panadol is a well known paracetamol.
The drug is mainly produced in forms for oral administration (conventional and effervescent tablets, capsules). For children medication exists in the form of syrups and suppositories. A dose of one tablet for adults is 500 mg. There is still a Panadol Extra, which additionally contains caffeine. Sold in cartons of 12 pieces in blister.
Produces this medication pharmaceutical company GlaxoSmithKline (Ireland).
Mechanism of action
The current component of Panadol, paracetamol, refers to non-selective non-steroidal anti-inflammatory drugs. The paracetamol has a powerful antipyretic, analgesic and moderate anti-inflammatory effect is minimal.
The principle of operation is associated with the blocking of the enzyme ciclooxigenasa that leads to inhibition of the synthesis of prostaglandins (the main substances that cause pain, inflammation and fever). It is important to note that paracetamol, in addition to peripheral actions, has a Central. So it is used even in combination with narcotic analgesics for treatment of pain in cancer patients.
The drug is well absorbed into the systemic circulation from the gastrointestinal tract. Begins to act after only 20 minutes. The maximum effect is observed after 40-120 minutes after taking the pill. Metabolism of paracetamol occurs in the liver, you need to consider when prescribing medication to people with chronic diseases of this organ, as well as long-term use of the drug (need to periodically monitor liver function).
Most often used Panadol for a headache and for the relief of fever. The medicine quickly and reliably eliminates cephalalgia, regardless of the cause. The drug is effective even when
How to take Panadol
The medication is taken orally, no need to grind or chew. You need to drink plenty of fluids. Effervescent tablets (Panadol Soluble) is dissolved in cold boiled water.
Single and course dose determined by the specialist for each person individually. The recommended dose for children twelve years old and adults is 0.5-1 g (1-2 pills) on time. The number of doses 3-4 times a day. The maximum amount per day should not exceed 4 grams, that is 8 pills.
Children aged 6 to 12 years old fashionable to use at the time 250-500 mg Panadol, the number of receptions is 3-4 times a day. The maximum amount of medication for them should not exceed 2 grams per day.
Can't drink Panadol for more than 7days to use the drug on an empty stomach. It is also important to note that persons with pathology of the liver and kidneys need adjustment of dosages in the smaller side.
Side effects and contraindications
The drug is contraindicated:
- Allergy to paracetamol or other components of the tablet;
- chronic diseases of the liver and kidneys, which caused failure of these organs;
- jaundice of obscure origin;
- a genetic deficiency of the enzyme G-6-PDG;
- diseases of the blood system, in particular the syndrome of anemia and leukopenia;
- people suffering from alcoholism due to the damaging effects on the liver.
The drug is usually well tolerated by patients, but when used Panadol can develop the following side effects:
- abdominal pain, nausea and vomiting;
- increasing the concentration of liver enzymes;
- inhibition of the hematopoietic system with the development of anemia, leukopenia, thrombocytopenia, agranulocytosis;
- the development of this state as methemoglobinaemia;
- various hypersensitivity reactions (skin rash, itching, swelling, anaphylaxis);
- hypoglycemia (low glucose concentration) that must be considered in patients with diabetes;
- the development of toxic hepatitis or nephritis.
Reception during pregnancy and lactation
Paracetamol is the only drug which is allowed for use in fever and
May occur with a significant excess of the specified doses. This leads to the development of severe liver damage, abdominal pain, nausea, vomiting. There may come a hypoglycemic coma, bleeding of different localization.
First aid is gastric lavage, administration of absorbents. The specific antidote is the acetylcysteine, which is prescribed in first day after poisoning.
Price, reviews and terms of release from pharmacies
The average price of Panadol (12 tablets of 500 mg) is 50-100 rubles. The drug is included in the OTC group and dispensed in pharmacies freely.
Video on the dangers of overdose paracetamol (Panadol):
Reviews about Panadole:
“Since young people suffer from migraine headaches. As a rule, take an Advil, Nurofen. The last attack I had at work, tablets at hand was not. Ran to the pharmacy, the pharmacist advised me to try Panadol Extra (paracetamol and caffeine). The headache vanished after the first pill. Now always carry in my purse is a miracle cure.”
“Met with Panadol medicine on the advice of a friend. Once I got sick but could not afford to lie down, as on the nose was another exam of the winter session. Took Panadol: 1 tablet 3times a day. Immediately after the first temperature returned to normal, my head cleared up, which enabled us to fill up the session.”